Assay Detail
Functional
CHEMBL770817
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Evaluated for antagonism of AII contracted rabbit aortic rings
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1H-1,2,4-triazole angiotensin II receptor antagonists: N-phenylpyridinylmethyl and N-pyridinylphenylmethyl analogs of SC-50560
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85595 | — | — | 1 | 8.70 |
| CHEMBL315021 | FORASARTAN | 2.0 | 1 | 8.20 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.10 |
| CHEMBL315022 | — | — | 1 | 8.00 |
| CHEMBL87411 | — | — | 1 | 7.20 |
| CHEMBL88067 | — | — | 1 | 6.90 |
| CHEMBL86344 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85595 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL315021 | FORASARTAN | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL191 | LOSARTAN | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL315022 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL87411 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL88067 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL86344 | — | Kd | = | 158.49 | nM | 6.80 |