Assay Detail
Functional
CHEMBL770827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for agonist potency from plots of percentage 5-HT (1 uM) response against concentration of the agonist in white rabbit saphenous vein
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Saphenous vein |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogues: Potent and selective agonists for 5-HT1D receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.37 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296161 | — | — | 1 | 7.50 |
| CHEMBL53739 | — | — | 1 | 7.41 |
| CHEMBL54265 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296161 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL53739 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL54265 | — | EC50 | = | 62.0 | nM | 7.21 |