Assay Detail
Functional
CHEMBL770850
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Cytotoxic activity against human lymphoblast tumor cell line RPMI8402 after 4 days of treatment
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI 8402 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.24 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71086 | — | — | 1 | 9.00 |
| CHEMBL70790 | — | — | 1 | 8.70 |
| CHEMBL309355 | — | — | 1 | 8.70 |
| CHEMBL72772 | — | — | 1 | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.30 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.92 |
| CHEMBL309352 | — | — | 1 | 7.60 |
| CHEMBL415117 | — | — | 1 | 7.22 |
| CHEMBL72223 | — | — | 1 | 7.10 |
| CHEMBL452231 | TENIPOSIDE | 4.0 | 1 | 6.66 |
| CHEMBL73950 | — | — | 1 | 6.62 |
| CHEMBL72726 | — | — | 1 | 6.47 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 6.24 |
| CHEMBL306476 | — | — | 1 | 5.90 |
| CHEMBL304505 | — | — | 1 | 5.52 |
| CHEMBL424421 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71086 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL70790 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL309355 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL72772 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL309352 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL415117 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL72223 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL452231 | TENIPOSIDE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL73950 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL72726 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL306476 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL304505 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL424421 | — | IC50 | = | 4800.0 | nM | 5.32 |