Assay Detail
Functional
CHEMBL770903
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Inhibition of rabbit-osteoclast mediated resorption of dentine slices
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Dentine |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.67 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421024 | — | — | 1 | 6.10 |
| CHEMBL419360 | — | — | 1 | 5.52 |
| CHEMBL106442 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421024 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL419360 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL106442 | — | IC50 | = | 4000.0 | nM | 5.40 |