Assay Detail
Functional
CHEMBL770909
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Antagonistic activity through inhibition of A II induced contractions on rabbit aortic strips
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.71 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL938 | SARALASIN | 4.0 | 1 | 8.64 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.40 |
| CHEMBL325201 | — | — | 1 | 7.92 |
| CHEMBL324452 | — | — | 1 | 7.64 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.60 |
| CHEMBL419583 | — | — | 1 | 7.57 |
| CHEMBL116170 | — | — | 1 | 7.42 |
| CHEMBL114656 | — | — | 1 | 7.41 |
| CHEMBL113674 | — | — | 1 | 7.38 |
| CHEMBL327018 | — | — | 1 | 7.28 |
| CHEMBL114267 | — | — | 1 | 7.28 |
| CHEMBL439968 | — | — | 1 | 7.20 |
| CHEMBL114720 | — | — | 1 | 7.16 |
| CHEMBL114710 | — | — | 1 | 7.10 |
| CHEMBL44268 | — | — | 1 | 6.96 |
| CHEMBL114687 | — | — | 1 | 6.96 |
| CHEMBL290988 | — | — | 1 | 6.92 |
| CHEMBL115984 | — | — | 1 | 6.89 |
| CHEMBL325445 | — | — | 1 | 6.70 |
| CHEMBL115193 | — | — | 1 | 6.70 |
| CHEMBL114983 | — | — | 1 | 6.62 |
| CHEMBL113039 | — | — | 1 | 6.60 |
| CHEMBL296883 | — | — | 1 | 6.57 |
| CHEMBL325684 | — | — | 1 | 6.47 |
| CHEMBL323244 | — | — | 1 | 6.47 |
| CHEMBL324245 | — | — | 1 | 6.46 |
| CHEMBL112343 | — | — | 1 | 6.38 |
| CHEMBL115492 | — | — | 1 | 6.32 |
| CHEMBL324785 | — | — | 1 | 6.22 |
| CHEMBL114771 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL938 | SARALASIN | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL325201 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL324452 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL191 | LOSARTAN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL419583 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL116170 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL114656 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL113674 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL327018 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL114267 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL439968 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL114720 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL114710 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL114687 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL44268 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL290988 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL115984 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL325445 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL115193 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL114983 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL113039 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL296883 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL325684 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL323244 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL324245 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL112343 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL115492 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL324785 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL114771 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL115771 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL46782 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL325751 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL45493 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL423325 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL324888 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL113701 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL115835 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL410724 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325502 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL332051 | — | IC50 | > | 10000.0 | nM | - |