Assay Detail
Functional
CHEMBL771387
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Compound was tested for its antagonistic activity against angiotensin II-induced contractions in rabbit aorta
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.63 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1069 | VALSARTAN | 4.0 | 1 | 8.85 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1069 | VALSARTAN | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 4.0 | nM | 8.40 |