Assay Detail
Functional
CHEMBL771388
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Vasorelaxation activity in the isolated endothelium-denuded rabbit aorta
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New antianginal nitro esters with reduced hypotensive activity. Synthesis and pharmacological evaluation of 3-[(nitrooxy)alkyl]-2H-1,3-benzoxazin-4(3H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.02 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL730 | NITROGLYCERIN | 4.0 | 1 | 7.80 |
| CHEMBL26266 | — | — | 1 | 7.68 |
| CHEMBL30040 | — | — | 1 | 7.46 |
| CHEMBL287213 | — | — | 1 | 7.43 |
| CHEMBL413318 | — | — | 1 | 7.33 |
| CHEMBL29361 | — | — | 1 | 7.16 |
| CHEMBL29924 | — | — | 1 | 7.15 |
| CHEMBL284728 | — | — | 1 | 7.11 |
| CHEMBL27129 | SINITRODIL | 2.0 | 1 | 7.03 |
| CHEMBL27402 | — | — | 1 | 7.01 |
| CHEMBL29691 | — | — | 1 | 6.96 |
| CHEMBL29618 | — | — | 1 | 6.90 |
| CHEMBL29935 | — | — | 1 | 6.64 |
| CHEMBL285845 | — | — | 1 | 6.44 |
| CHEMBL27244 | — | — | 1 | 6.19 |
| CHEMBL284906 | NICORANDIL | 3.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL730 | NITROGLYCERIN | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL26266 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL30040 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL287213 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL413318 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL29361 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL29924 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL284728 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL27129 | SINITRODIL | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL27402 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL29691 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL29618 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL29935 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL285845 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL27244 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL284906 | NICORANDIL | IC50 | = | 1100.0 | nM | 5.96 |