Assay Detail
Functional
CHEMBL771603
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In vitro inhibition of potassium-contracted rabbit aorta strips
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.62 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322279 | — | — | 1 | 8.70 |
| CHEMBL111202 | — | — | 1 | 8.70 |
| CHEMBL1491 | AMLODIPINE | 4.0 | 1 | 8.52 |
| CHEMBL109475 | — | — | 1 | 8.40 |
| CHEMBL109782 | — | — | 1 | 8.30 |
| CHEMBL324655 | — | — | 1 | 8.30 |
| CHEMBL325796 | — | — | 1 | 8.15 |
| CHEMBL110206 | — | — | 1 | 8.10 |
| CHEMBL114232 | — | — | 1 | 8.05 |
| CHEMBL113496 | — | — | 1 | 7.92 |
| CHEMBL325314 | — | — | 1 | 7.82 |
| CHEMBL440695 | — | — | 1 | 7.77 |
| CHEMBL113248 | — | — | 1 | 7.66 |
| CHEMBL322510 | — | — | 1 | 7.64 |
| CHEMBL109821 | — | — | 1 | 7.54 |
| CHEMBL110023 | — | — | 1 | 7.47 |
| CHEMBL87921 | — | — | 1 | 7.39 |
| CHEMBL321033 | — | — | 1 | 7.30 |
| CHEMBL111354 | — | — | 1 | 7.30 |
| CHEMBL320713 | — | — | 1 | 7.26 |
| CHEMBL541723 | — | — | 1 | 7.24 |
| CHEMBL110303 | — | — | 1 | 7.19 |
| CHEMBL109302 | — | — | 1 | 7.14 |
| CHEMBL111662 | — | — | 1 | 7.01 |
| CHEMBL320129 | — | — | 1 | 6.92 |
| CHEMBL108139 | — | — | 1 | 6.89 |
| CHEMBL110311 | — | — | 1 | 6.44 |
| CHEMBL322261 | — | — | 1 | 6.10 |
| CHEMBL86889 | — | — | 1 | - |
| CHEMBL326871 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322279 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL111202 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1491 | AMLODIPINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL109475 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL109782 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL324655 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL325796 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL110206 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL114232 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL113496 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL325314 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL440695 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL113248 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL322510 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL109821 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL110023 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL87921 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL321033 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL111354 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL320713 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL541723 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL110303 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL109302 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL111662 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL320129 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL108139 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL110311 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL322261 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL86889 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL326871 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL111366 | — | IC50 | > | 1000.0 | nM | - |