Assay Detail
Functional
CHEMBL771610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of twitch height in electrically stimulated rabbit vas deferens
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines .
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.03 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308608 | — | — | 1 | 8.52 |
| CHEMBL420007 | — | — | 1 | 8.52 |
| CHEMBL306395 | — | — | 1 | 8.15 |
| CHEMBL76161 | — | — | 1 | 8.05 |
| CHEMBL74358 | — | — | 1 | 7.66 |
| CHEMBL74301 | — | — | 1 | 7.58 |
| CHEMBL75704 | — | — | 1 | 7.37 |
| CHEMBL308744 | — | — | 1 | 7.33 |
| CHEMBL76296 | — | — | 1 | 7.32 |
| CHEMBL73338 | — | — | 1 | 6.97 |
| CHEMBL72908 | — | — | 1 | 6.44 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 6.34 |
| CHEMBL307645 | — | — | 1 | 6.27 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 6.26 |
| CHEMBL74300 | — | — | 1 | 6.18 |
| CHEMBL308168 | — | — | 1 | 5.52 |
| CHEMBL74786 | — | — | 1 | 5.00 |
| CHEMBL75552 | — | — | 1 | - |
| CHEMBL76107 | — | — | 1 | - |
| CHEMBL309093 | — | — | 1 | - |
| CHEMBL308381 | — | — | 1 | - |
| CHEMBL73149 | — | — | 1 | - |
| CHEMBL306941 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308608 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL420007 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL306395 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL76161 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL74358 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL74301 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL75704 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL308744 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL76296 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL73338 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL72908 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL14 | CARBACHOL | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL307645 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL74300 | — | IC50 | = | 659.0 | nM | 6.18 |
| CHEMBL308168 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL74786 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL75552 | — | IC50 | = | 0.004 | nM | - |
| CHEMBL76107 | — | IC50 | = | 0.006 | nM | - |
| CHEMBL309093 | — | IC50 | = | 0.001 | nM | - |
| CHEMBL308381 | — | IC50 | = | 0.002 | nM | - |
| CHEMBL73149 | — | IC50 | = | 0.008 | nM | - |
| CHEMBL306941 | — | IC50 | = | 0.003 | nM | - |