Assay Detail
Functional
CHEMBL771616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal artery vascular smooth muscle cells
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.85 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406279 | — | — | 1 | 6.48 |
| CHEMBL85341 | — | — | 1 | 6.37 |
| CHEMBL313056 | — | — | 1 | 6.22 |
| CHEMBL315047 | — | — | 1 | 6.20 |
| CHEMBL87243 | — | — | 1 | 5.82 |
| CHEMBL2370070 | — | — | 1 | 5.70 |
| CHEMBL313984 | — | — | 2 | 5.66 |
| CHEMBL86814 | — | — | 1 | 5.51 |
| CHEMBL289687 | — | — | 1 | 5.50 |
| CHEMBL327350 | — | — | 1 | 5.35 |
| CHEMBL431874 | — | — | 1 | - |
| CHEMBL86737 | — | — | 1 | - |
| CHEMBL315780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406279 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL85341 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL313056 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL315047 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL87243 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2370070 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL313984 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL313984 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL86814 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL289687 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL327350 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL431874 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL86737 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL315780 | — | IC50 | > | 10000.0 | nM | - |