Assay Detail
Functional
CHEMBL771890
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The compound was evaluated for the inhibition of Na+-dependent [3H]taurocholate uptake into ileal brush border membrane vesicles in rabbit, by 50%
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Specific inhibitors of ileal bile acid transport.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.42 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405832 | — | — | 1 | 4.72 |
| CHEMBL185878 | TAUROCHENODEOXYCHOLATE | — | 1 | 4.55 |
| CHEMBL170114 | — | — | 1 | 4.32 |
| CHEMBL205596 | CHOLIC ACID | 4.0 | 1 | 4.08 |
| CHEMBL267171 | — | — | 1 | - |
| CHEMBL171151 | — | — | 1 | - |
| CHEMBL170065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405832 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL185878 | TAUROCHENODEOXYCHOLATE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL170114 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL205596 | CHOLIC ACID | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL267171 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL171151 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL170065 | — | IC50 | > | 250000.0 | nM | - |