Assay Detail
Binding
CHEMBL772116
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Displacement of [3H]-PDBu from protein kinase C gamma-C1B domain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.56 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102858 | — | — | 1 | 6.17 |
| CHEMBL103091 | — | — | 1 | 5.76 |
| CHEMBL102991 | — | — | 1 | 5.55 |
| CHEMBL318971 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102858 | — | Ki | = | 675.0 | nM | 6.17 |
| CHEMBL103091 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL102991 | — | Ki | = | 2820.0 | nM | 5.55 |
| CHEMBL318971 | — | Ki | = | 17600.0 | nM | 4.75 |