Assay Detail
Functional
CHEMBL772133
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Tested for inhibition of Angiotensin II-induced pressor response in rabbit aorta
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Valsartan, a potent, orally active angiotensin II antagonist developed from the structurally new amino acid series
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.44 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1069 | VALSARTAN | 4.0 | 1 | 8.85 |
| CHEMBL116298 | — | — | 1 | 8.52 |
| CHEMBL112523 | — | — | 1 | 7.96 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.62 |
| CHEMBL326349 | — | — | 1 | 7.17 |
| CHEMBL323911 | — | — | 1 | 7.17 |
| CHEMBL115622 | — | — | 1 | 7.00 |
| CHEMBL114653 | — | — | 1 | 6.98 |
| CHEMBL115783 | — | — | 1 | 6.85 |
| CHEMBL117941 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1069 | VALSARTAN | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL116298 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL112523 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL191 | LOSARTAN | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL326349 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL323911 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL115622 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL114653 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL115783 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL117941 | — | IC50 | = | 500.0 | nM | 6.30 |