Assay Detail
Functional
CHEMBL772315
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant potency in isolated potassium (K(+)-depolarized rabbit thoracic aorta.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.09 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475534 | NITRENDIPINE | 3.0 | 1 | 9.00 |
| CHEMBL3392282 | — | — | 1 | 8.40 |
| CHEMBL3392286 | — | — | 1 | 8.22 |
| CHEMBL2398396 | — | — | 1 | 8.15 |
| CHEMBL3392281 | — | — | 1 | 8.05 |
| CHEMBL3392283 | — | — | 1 | 7.80 |
| CHEMBL3392280 | — | — | 1 | 7.58 |
| CHEMBL3392284 | — | — | 1 | 7.52 |
| CHEMBL3392285 | — | — | 1 | 7.44 |
| CHEMBL39925 | — | — | 1 | 6.89 |
| CHEMBL3392289 | — | — | 1 | 6.77 |
| CHEMBL472962 | — | — | 1 | 6.75 |
| CHEMBL515270 | — | — | 1 | 6.72 |
| CHEMBL282279 | — | — | 1 | 6.55 |
| CHEMBL3392279 | — | — | 1 | 6.52 |
| CHEMBL287887 | — | — | 1 | 6.52 |
| CHEMBL88149 | — | — | 1 | 6.15 |
| CHEMBL3392277 | — | — | 1 | 5.92 |
| CHEMBL3392288 | — | — | 1 | 5.72 |
| CHEMBL3392278 | — | — | 1 | 5.21 |
| CHEMBL3392287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475534 | NITRENDIPINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3392282 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3392286 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2398396 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3392281 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3392283 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3392280 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3392284 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3392285 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL39925 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3392289 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL472962 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL515270 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL282279 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3392279 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL287887 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL88149 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3392277 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3392288 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3392278 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3392287 | — | IC50 | > | 100000.0 | nM | - |