Assay Detail
Functional
CHEMBL772346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of the twitch response in the electrically stimulated rabbit vas deferens
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of heterocyclic analogues of the functional M1 selective muscarinic agonist hexyloxy-TZTP
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.78 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 11.00 |
| CHEMBL101054 | — | — | 1 | 7.82 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 6.26 |
| CHEMBL74300 | — | — | 1 | 6.18 |
| CHEMBL74786 | — | — | 1 | 5.00 |
| CHEMBL168581 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21536 | XANOMELINE | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL101054 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL74300 | — | IC50 | = | 659.0 | nM | 6.18 |
| CHEMBL74786 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL168581 | — | IC50 | = | 39000.0 | nM | 4.41 |