Assay Detail
Functional
CHEMBL772349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for ability to relax potassium-contracted rabbit aorta smooth muscle
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies directed toward ascertaining the active conformation of 1,4-dihydropyridine calcium entry blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.91 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 9.30 |
| CHEMBL177144 | — | — | 1 | 9.00 |
| CHEMBL63997 | — | — | 1 | 8.52 |
| CHEMBL25676 | — | — | 1 | 8.40 |
| CHEMBL25312 | — | — | 1 | 7.96 |
| CHEMBL63315 | — | — | 1 | 7.87 |
| CHEMBL172829 | — | — | 1 | 6.73 |
| CHEMBL1098881 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL177144 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL63997 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL25676 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL25312 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL63315 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL172829 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL1098881 | — | IC50 | = | 3050.0 | nM | 5.52 |