Assay Detail
Functional
CHEMBL772350
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Compound was tested for its inhibition of ET-1 induced arachidonic acid accumulation in rabbit renal artery vascular smooth muscle cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of C-terminal peptide antagonists of endothelin: structure-activity relationships of ET-[1621, D-His16]
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.67 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147908 | — | — | 1 | 6.22 |
| CHEMBL146155 | — | — | 1 | 5.80 |
| CHEMBL2370070 | — | — | 1 | 5.70 |
| CHEMBL313984 | — | — | 1 | 5.58 |
| CHEMBL86814 | — | — | 1 | 5.51 |
| CHEMBL289687 | — | — | 1 | 5.50 |
| CHEMBL327350 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147908 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL146155 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2370070 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL313984 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL86814 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL289687 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL327350 | — | IC50 | = | 4500.0 | nM | 5.35 |