Assay Detail
Functional
CHEMBL772463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition U-46619 (3 x10 E -8 M) induced vascular contraction (TXA2 tao receptor) in rabbit thoracic aorta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.63 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262655 | — | — | 1 | 7.64 |
| CHEMBL77223 | — | — | 1 | 7.01 |
| CHEMBL74674 | — | — | 1 | 5.96 |
| CHEMBL8273 | SULOTROBAN | 2.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262655 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL77223 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL74674 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL8273 | SULOTROBAN | IC50 | = | 1300.0 | nM | 5.89 |