Assay Detail
Functional
CHEMBL772473
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for inhibition of Angiotensin-II induced rabbit aorta strips contraction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.01 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1016 | CANDESARTAN | 3.0 | 1 | 9.70 |
| CHEMBL303264 | — | — | 1 | 8.72 |
| CHEMBL308911 | — | — | 1 | 6.88 |
| CHEMBL304360 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1016 | CANDESARTAN | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL303264 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL308911 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL304360 | — | IC50 | = | 191.0 | nM | 6.72 |