Assay Detail
Functional
CHEMBL772501
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Relaxant effect on rabbit corpus cavernosum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Corpus cavernosum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.82 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540294 | — | — | 1 | 8.30 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.10 |
| CHEMBL77971 | — | — | 1 | 8.10 |
| CHEMBL541823 | — | — | 1 | 7.85 |
| CHEMBL539783 | — | — | 1 | 7.66 |
| CHEMBL542410 | — | — | 1 | 7.43 |
| CHEMBL540031 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540294 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL192 | SILDENAFIL | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL77971 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL541823 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL539783 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL542410 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL540031 | — | EC50 | = | 53.0 | nM | 7.28 |