Assay Detail

CHEMBL772502

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Functional

Stimulation of acid secretion from rabbit parietal glands

ChEMBL ↗

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Target

Oryctolagus cuniculus (CHEMBL374) ↗

Open DB target context

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Oryctolagus cuniculus (CHEMBL374) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Oryctolagus cuniculus

CHEMBL374

Anchored from Assay target.

Protein identity Oryctolagus cuniculus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Oryctolagus cuniculus
Confidence	1 — Organism
Curated By	Expert

Target

Oryctolagus cuniculus (CHEMBL374) ↗

Type	ORGANISM
Organism	Oryctolagus cuniculus

Publication

1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.

Christensen SB, Guider A, Forster CJ, Gleason JG, Bender PE, Karpinski JM, DeWolf WE, Barnette MS, Underwood DC, Griswold DE, Cieslinski LB, Burman M, Bochnowicz S, Osborn RR, Manning CD, Grous M, Hillegas LM, Bartus JO, Ryan MD, Eggleston DS, Haltiwanger RC, Torphy TJ.
J Med Chem (1998) 41 : 821 -835
PubMed 9526558 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	7.25	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL430893	(-)-ROLIPRAM	—	1	8.40
CHEMBL511115	CILOMILAST	3.0	1	6.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL430893	(-)-ROLIPRAM	EC50	=	4.0	nM	8.40
CHEMBL511115	CILOMILAST	EC50	=	800.0	nM	6.10