Assay Detail
Functional
CHEMBL772784
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Evaluated for antagonism of angiotensin II induced contraction of rabbit aorta rings
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.85 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12810 | — | — | 1 | 8.00 |
| CHEMBL276150 | — | — | 1 | 7.70 |
| CHEMBL12451 | — | — | 1 | 7.70 |
| CHEMBL12548 | — | — | 1 | 6.70 |
| CHEMBL12693 | — | — | 1 | 6.40 |
| CHEMBL12737 | — | — | 1 | 6.30 |
| CHEMBL267547 | — | — | 1 | 6.10 |
| CHEMBL276381 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12810 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL276150 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL12451 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL12548 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL12693 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL12737 | — | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL267547 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL276381 | — | Kd | = | 1258.93 | nM | 5.90 |