Assay Detail
Functional
CHEMBL772785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for antagonism of angiotensin II induced contraction of rabbit aorta rings.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.03 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.10 |
| CHEMBL274447 | — | — | 1 | 7.10 |
| CHEMBL12190 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL274447 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL12190 | — | Kd | = | 1258.93 | nM | 5.90 |