Assay Detail
Functional
CHEMBL772789
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of angiotensin II induced contraction in rabbit aortic strips after 60 minutes contact with the compound
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.19 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87327 | — | — | 1 | 8.48 |
| CHEMBL86247 | — | — | 1 | 8.40 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.00 |
| CHEMBL84573 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87327 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL86247 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL191 | LOSARTAN | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL84573 | — | IC50 | = | 13.0 | nM | 7.89 |