Assay Detail
Functional
CHEMBL772790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Calcium channel-blocking activity by determined by ability to antagonize calcium-induced contractions of isolated rabbit aortic strips
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, calcium-channel-blocking activity, and antihypertensive activity of 4-(diarylmethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 60 | 8.25 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 9.80 |
| CHEMBL322374 | — | — | 1 | 9.00 |
| CHEMBL322419 | — | — | 1 | 8.90 |
| CHEMBL102564 | — | — | 1 | 8.90 |
| CHEMBL100902 | — | — | 1 | 8.90 |
| CHEMBL319450 | — | — | 1 | 8.80 |
| CHEMBL319018 | — | — | 1 | 8.80 |
| CHEMBL100249 | — | — | 1 | 8.80 |
| CHEMBL103777 | — | — | 1 | 8.70 |
| CHEMBL100495 | — | — | 1 | 8.70 |
| CHEMBL99677 | — | — | 1 | 8.70 |
| CHEMBL102386 | — | — | 1 | 8.70 |
| CHEMBL319807 | — | — | 1 | 8.60 |
| CHEMBL103967 | — | — | 1 | 8.60 |
| CHEMBL322220 | — | — | 1 | 8.60 |
| CHEMBL318768 | — | — | 1 | 8.60 |
| CHEMBL102696 | — | — | 1 | 8.60 |
| CHEMBL103353 | — | — | 1 | 8.60 |
| CHEMBL103608 | — | — | 1 | 8.60 |
| CHEMBL17254 | — | — | 1 | 8.60 |
| CHEMBL106495 | — | — | 1 | 8.60 |
| CHEMBL103383 | — | — | 1 | 8.50 |
| CHEMBL102549 | — | — | 1 | 8.50 |
| CHEMBL105114 | — | — | 1 | 8.50 |
| CHEMBL321093 | — | — | 1 | 8.50 |
| CHEMBL105090 | — | — | 1 | 8.50 |
| CHEMBL323560 | — | — | 1 | 8.40 |
| CHEMBL317258 | — | — | 1 | 8.40 |
| CHEMBL319491 | — | — | 1 | 8.30 |
| CHEMBL103209 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | Kd | = | 0.1585 | nM | 9.80 |
| CHEMBL322374 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL322419 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL102564 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL100902 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL319450 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL319018 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL100249 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL100495 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL99677 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL102386 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL103777 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL106495 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL17254 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL103608 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL318768 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL103353 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL102696 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL322220 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL103967 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL319807 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL105090 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL321093 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL102549 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL103383 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL105114 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL323560 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL317258 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL319491 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL103209 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL30008 | FLUNARIZINE | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL101086 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL105165 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL319619 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL102523 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL100074 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL273552 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL100304 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL318985 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL103830 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL321340 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL17436 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL321804 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL6966 | VERAPAMIL | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL420270 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL106496 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL103587 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL101346 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL101005 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL105534 | — | Kd | = | 19.95 | nM | 7.70 |