Assay Detail
Functional
CHEMBL772962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonist activity was determined by the ability to antagonize the contractile response to angiotensin II in the isolated rabbit aortic strips
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of new arylthiophene analogs of DuP 753
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.53 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.21 |
| CHEMBL274447 | — | — | 1 | 6.92 |
| CHEMBL300882 | — | — | 1 | 6.48 |
| CHEMBL50204 | — | — | 1 | 6.48 |
| CHEMBL409552 | — | — | 1 | 5.70 |
| CHEMBL50135 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL274447 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL300882 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL50204 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL409552 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL50135 | — | IC50 | = | 4160.0 | nM | 5.38 |