Assay Detail
Functional
CHEMBL773451
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In vitro contractile activity was measured in the rabbit duodenum preparation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Macrolide-type motilin receptor agonists: Assessment of the biological value of the 2- and 4-hydroxyl groups of acid-stable 8,9-anhydroerythromycin A 6,9-hemiacetals
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.49 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289955 | — | — | 1 | 8.21 |
| CHEMBL43313 | — | — | 1 | 8.04 |
| CHEMBL297168 | — | — | 1 | 7.98 |
| CHEMBL27424 | — | — | 1 | 7.41 |
| CHEMBL265495 | — | — | 1 | 7.36 |
| CHEMBL26966 | — | — | 1 | 7.32 |
| CHEMBL27419 | — | — | 1 | 6.93 |
| CHEMBL45141 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289955 | — | EC50 | = | 6.166 | nM | 8.21 |
| CHEMBL43313 | — | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL297168 | — | EC50 | = | 10.47 | nM | 7.98 |
| CHEMBL27424 | — | EC50 | = | 38.9 | nM | 7.41 |
| CHEMBL265495 | — | EC50 | = | 43.65 | nM | 7.36 |
| CHEMBL26966 | — | EC50 | = | 47.86 | nM | 7.32 |
| CHEMBL27419 | — | EC50 | = | 117.49 | nM | 6.93 |
| CHEMBL45141 | — | EC50 | = | 208.93 | nM | 6.68 |