Assay Detail
Functional
CHEMBL773452
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Serotonergic activity was assessed in vitro on the New Zealand white rabbit saphenous vein preparation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Saphenous vein |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.20 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37462 | — | — | 1 | 8.00 |
| CHEMBL289489 | — | — | 1 | 7.90 |
| CHEMBL39435 | — | — | 1 | 7.90 |
| CHEMBL39317 | L-694247 | — | 1 | 7.80 |
| CHEMBL37317 | — | — | 1 | 6.80 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.80 |
| CHEMBL290587 | — | — | 1 | 6.70 |
| CHEMBL36497 | — | — | 1 | 6.60 |
| CHEMBL39243 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37462 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL289489 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL39435 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL39317 | L-694247 | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL37317 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL39 | SEROTONIN | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL290587 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL36497 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL39243 | — | EC50 | = | 501.19 | nM | 6.30 |