Assay Detail
Functional
CHEMBL774084
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Tested for inhibition of Na+ -dependent [3H]taurocholate uptake into rabbit ileal brush border membrane vesicles
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of bile acid-derived HMG-CoA reductase inhibitors. The role of 21-methyl in recognition of HMG-CoA reductase and the ileal bile acid transport system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.19 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185878 | TAUROCHENODEOXYCHOLATE | — | 1 | 4.55 |
| CHEMBL205596 | CHOLIC ACID | 4.0 | 1 | 4.08 |
| CHEMBL326894 | — | — | 1 | 4.07 |
| CHEMBL322338 | — | — | 1 | 4.04 |
| CHEMBL321906 | — | — | 1 | - |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | - |
| CHEMBL320943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185878 | TAUROCHENODEOXYCHOLATE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL205596 | CHOLIC ACID | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL326894 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL322338 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL321906 | — | IC50 | = | 186000.0 | nM | - |
| CHEMBL503 | LOVASTATIN | IC50 | > | 250000.0 | nM | - |
| CHEMBL320943 | — | IC50 | = | 170000.0 | nM | - |