Assay Detail
Functional
CHEMBL779292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of ACTH-stimulated corticosterone biosynthesis in rat adrenal slices
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.20 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294361 | — | — | 3 | 4.52 |
| CHEMBL304583 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294361 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL304583 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL294361 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL294361 | — | IC50 | = | 95000.0 | nM | 4.02 |