Assay Detail
Functional
CHEMBL779517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive inotropic activity on rat papillary muscle electrically stimulated by unipolar square wave pulses
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New 1,4-dihydropyridines endowed with NO-donor and calcium channel agonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.98 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082832 | — | — | 1 | 6.77 |
| CHEMBL91072 | — | — | 1 | 6.09 |
| CHEMBL91482 | — | — | 1 | 5.92 |
| CHEMBL327248 | — | — | 1 | 5.82 |
| CHEMBL90916 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082832 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL91072 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL91482 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL327248 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL90916 | — | EC50 | = | 5200.0 | nM | 5.28 |