Compound Detail
CHEMBL327248
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Basic Information
| ChEMBL ID | CHEMBL327248 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQNZNUKHQNYMKU-MNDPQUGUSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
411.4
MW (Da)
3.00
ALogP
10
HBA
1
HBD
156.9
PSA (Ų)
0.43
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | EC50 | 6.92 | 6.37 | 120.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | EC50 | = | 120.0 | nM | 6.92 | Capacity to increase [Ca2+] entry into the vascular smooth muscle was evaluated ... | 15115410 |
| Rattus norvegicus | EC50 | = | 1500.0 | nM | 5.82 | Positive inotropic activity on rat papillary muscle electrically stimulated by u... | 15115410 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15115410 | 10.1021/jm031109v | Rattus norvegicus | 3 |
| 15115410 | 10.1021/jm031109v | Voltage-gated L-type calcium channel | 1 |
Data from ChEMBL 36 via Core Engine