Assay Detail
Functional
CHEMBL780700
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Capacity to increase [Ca2+] entry into the vascular smooth muscle was evaluated on rat aorta strips partially depolarized with 10 mM K
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New 1,4-dihydropyridines endowed with NO-donor and calcium channel agonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.23 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082832 | — | — | 1 | 7.75 |
| CHEMBL91072 | — | — | 1 | 7.24 |
| CHEMBL91482 | — | — | 1 | 7.00 |
| CHEMBL327248 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082832 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL91072 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL91482 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL327248 | — | EC50 | = | 120.0 | nM | 6.92 |