Assay Detail
Functional
CHEMBL781538
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In vitro inhibition of the accumulation of (-)-[3H]-5-HT in synaptosomes from the rat brain cortex
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Homoallylic amines related to zimeldine. A comparative study on neuronal serotonin and norepinephrine reuptake based on conformational analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.47 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287064 | NOMELIDINE | 2.0 | 1 | 7.42 |
| CHEMBL173745 | NORZIMELIDINE | — | 1 | 7.10 |
| CHEMBL37744 | ZIMELDINE | 4.0 | 1 | 7.00 |
| CHEMBL354646 | — | — | 1 | 6.66 |
| CHEMBL170027 | — | — | 1 | 6.62 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 6.50 |
| CHEMBL172120 | — | — | 1 | 6.30 |
| CHEMBL367629 | — | — | 1 | 5.85 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 1 | 5.70 |
| CHEMBL174462 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287064 | NOMELIDINE | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL173745 | NORZIMELIDINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL37744 | ZIMELDINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL354646 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL170027 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL172120 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL367629 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL174462 | — | IC50 | = | 2600.0 | nM | 5.58 |