Compound Detail
CHEMBL173745
NORZIMELIDINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL173745 |
| Name | NORZIMELIDINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AZFZKANGXPSDEA-OVCLIPMQSA-N |
2
Targets
4
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
303.2
MW (Da)
3.50
ALogP
2
HBA
1
HBD
24.9
PSA (Ų)
0.93
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | IC50 | 8.34 | 7.72 | 4.6 | 2 |
| Mus musculus CHEMBL375 | IC50 | 6.1 | 5.85 | 800.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 66.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | IC50 | = | 4.6 | nM | 8.34 | In vitro inhibition of the accumulation of (-)-[3H]Norepinephrine in synaptosome... | 2966246 |
| Rattus norvegicus | IC50 | = | 80.0 | nM | 7.1 | In vitro inhibition of the accumulation of (-)-[3H]-5-HT in synaptosomes from th... | 2966246 |
| Mus musculus | IC50 | = | 800.0 | nM | 6.1 | In vitro inhibition of the accumulation of (-)-[3H]Norepinephrine in slices from... | 2966246 |
| Mus musculus | IC50 | = | 2500.0 | nM | 5.6 | In vitro inhibition of the accumulation of (-)-[3H]-5-HT in slices from the midd... | 2966246 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2966246 | 10.1021/jm00400a005 | Mus musculus | 4 |
| 2966246 | 10.1021/jm00400a005 | Rattus norvegicus | 2 |
| 2966246 | 10.1021/jm00400a005 | Unchecked | 2 |
| 17870541 | 10.1016/j.bmc.2007.08.060 | Homo sapiens | 1 |
Data from ChEMBL 36 via Core Engine