Assay Detail
Functional
CHEMBL740148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of the accumulation of (-)-[3H]Norepinephrine in slices from the middle part of the mouse brain.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Homoallylic amines related to zimeldine. A comparative study on neuronal serotonin and norepinephrine reuptake based on conformational analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.63 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367629 | — | — | 1 | 6.60 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 1 | 6.30 |
| CHEMBL173745 | NORZIMELIDINE | — | 1 | 6.10 |
| CHEMBL287064 | NOMELIDINE | 2.0 | 1 | 5.82 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 5.27 |
| CHEMBL354646 | — | — | 1 | 5.21 |
| CHEMBL174462 | — | — | 1 | 5.11 |
| CHEMBL37744 | ZIMELDINE | 4.0 | 1 | 4.62 |
| CHEMBL172120 | — | — | 1 | - |
| CHEMBL170027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367629 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL173745 | NORZIMELIDINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL287064 | NOMELIDINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL354646 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL174462 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL37744 | ZIMELDINE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL172120 | — | IC50 | > | 24000.0 | nM | - |
| CHEMBL170027 | — | IC50 | > | 25000.0 | nM | - |