Assay Detail
Functional
CHEMBL781691
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In vitro inhibition of the accumulation of (-)-[3H]Norepinephrine in synaptosomes from the rat brain cortex
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Homoallylic amines related to zimeldine. A comparative study on neuronal serotonin and norepinephrine reuptake based on conformational analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.43 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173745 | NORZIMELIDINE | — | 1 | 8.34 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 1 | 8.15 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 7.21 |
| CHEMBL354646 | — | — | 1 | 6.82 |
| CHEMBL287064 | NOMELIDINE | 2.0 | 1 | 6.62 |
| CHEMBL367629 | — | — | 1 | 6.00 |
| CHEMBL174462 | — | — | 1 | 5.85 |
| CHEMBL37744 | ZIMELDINE | 4.0 | 1 | 5.50 |
| CHEMBL170027 | — | — | 1 | 5.18 |
| CHEMBL172120 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173745 | NORZIMELIDINE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL354646 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL287064 | NOMELIDINE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL367629 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL174462 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL37744 | ZIMELDINE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL170027 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL172120 | — | IC50 | = | 22500.0 | nM | 4.65 |