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Assay Detail

CHEMBL781893

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of blood platelet aggregation (collagen) in rats
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Cyclic guanidines. 17. Novel (N-substituted amino)imidazo[2,1-b]quinazolin-2 ones: water-soluble platelet aggregation inhibitors.
Ishikawa F, Saegusa J, Inamura K, Sakuma K, Ashida S.
J Med Chem (1985) 28 : 1387 -1393
PubMed 4045917 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 5.90 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL760 ANAGRELIDE 4.0 1 7.70
CHEMBL31429 1 7.00
CHEMBL31722 1 7.00
CHEMBL31580 1 6.48
CHEMBL31283 1 6.36
CHEMBL31484 1 6.34
CHEMBL32132 1 6.24
CHEMBL31701 1 5.92
CHEMBL280984 1 5.92
CHEMBL31491 1 5.89
CHEMBL32455 1 5.85
CHEMBL31948 1 5.85
CHEMBL31502 1 5.82
CHEMBL31230 1 5.77
CHEMBL27619 1 5.72
CHEMBL289246 1 5.70
CHEMBL32456 1 5.64
CHEMBL31649 1 5.57
CHEMBL31465 1 5.52
CHEMBL29203 1 5.10
CHEMBL284053 1 4.80
CHEMBL31357 1 4.75
CHEMBL31356 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL760 ANAGRELIDE EC50 = 20.0 nM 7.70
CHEMBL31429 EC50 = 100.0 nM 7.00
CHEMBL31722 EC50 = 100.0 nM 7.00
CHEMBL31580 EC50 = 330.0 nM 6.48
CHEMBL31283 EC50 = 440.0 nM 6.36
CHEMBL31484 EC50 = 460.0 nM 6.34
CHEMBL32132 EC50 = 580.0 nM 6.24
CHEMBL31701 EC50 = 1200.0 nM 5.92
CHEMBL280984 EC50 = 1200.0 nM 5.92
CHEMBL31491 EC50 = 1300.0 nM 5.89
CHEMBL32455 EC50 = 1400.0 nM 5.85
CHEMBL31948 EC50 = 1400.0 nM 5.85
CHEMBL31502 EC50 = 1500.0 nM 5.82
CHEMBL31230 EC50 = 1700.0 nM 5.77
CHEMBL27619 EC50 = 1900.0 nM 5.72
CHEMBL289246 EC50 = 2000.0 nM 5.70
CHEMBL32456 EC50 = 2300.0 nM 5.64
CHEMBL31649 EC50 = 2700.0 nM 5.57
CHEMBL31465 EC50 = 3000.0 nM 5.52
CHEMBL29203 EC50 = 8000.0 nM 5.10
CHEMBL284053 EC50 = 16000.0 nM 4.80
CHEMBL31357 EC50 = 18000.0 nM 4.75
CHEMBL31356 EC50 = 20000.0 nM 4.70