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Compound Detail

CHEMBL31491

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CCN(CC)c1ccc2c(c1Cl)CN1CC(=O)NC1=N2

Basic Information

ChEMBL ID CHEMBL31491
Phase Preclinical
Structure Type MOL
InChI Key JBRUFHWOTAXGBW-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

292.8
MW (Da)
2.12
ALogP
4
HBA
1
HBD
47.9
PSA (Ų)
0.93
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H17ClN4O
MW 292.77
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness -1.00

Activity Summary

EC50 2 meas. best 5.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Rattus norvegicus
CHEMBL376
EC50 5.89 5.57 1300.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
4045917 10.1021/jm00148a003 Rattus norvegicus 4

Data from ChEMBL 36 via Core Engine