Assay Detail
Functional
CHEMBL782608
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Inhibition of Norepinephrine uptake from rat diencephalon-midbrain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.28 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 7.57 |
| CHEMBL277498 | NIPECOTIC ACID | — | 1 | 4.80 |
| CHEMBL158563 | — | — | 1 | 4.52 |
| CHEMBL103623 | — | — | 1 | 4.24 |
| CHEMBL38686 | — | — | 1 | - |
| CHEMBL77626 | — | — | 1 | - |
| CHEMBL160709 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL277498 | NIPECOTIC ACID | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL158563 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL103623 | — | IC50 | = | 58200.0 | nM | 4.24 |
| CHEMBL38686 | — | IC50 | = | 116600.0 | nM | - |
| CHEMBL77626 | — | IC50 | = | 123100.0 | nM | - |
| CHEMBL160709 | — | IC50 | = | 180000.0 | nM | - |