Assay Detail
Functional
CHEMBL783515
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Inhibitory effect on the binding of 2 nM [3H]naloxone to rat brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A photoaffinity reagent to label the opiate receptors of guinea pig ileum and mouse vas deferens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.81 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2371596 | — | — | 1 | 8.60 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 8.19 |
| CHEMBL2311114 | — | — | 1 | 7.52 |
| CHEMBL35838 | [LEU5]ENKEPHALIN | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2371596 | — | IC50 | = | 2.52 | nM | 8.60 |
| CHEMBL80 | NALOXONE | IC50 | = | 6.39 | nM | 8.19 |
| CHEMBL2311114 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL35838 | [LEU5]ENKEPHALIN | IC50 | = | 118.0 | nM | 6.93 |