Assay Detail
Functional
CHEMBL783636
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice.
12
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid ampa receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.76 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16315 | — | — | 2 | 5.75 |
| CHEMBL16303 | — | — | 3 | 4.87 |
| CHEMBL16360 | — | — | 1 | 4.82 |
| CHEMBL279120 | — | — | 1 | 4.81 |
| CHEMBL16261 | — | — | 1 | 4.56 |
| CHEMBL17098 | — | — | 1 | 4.36 |
| CHEMBL16342 | — | — | 1 | 4.11 |
| CHEMBL16589 | — | — | 1 | - |
| CHEMBL279648 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16315 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL16315 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL16303 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL16303 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL16360 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL279120 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL16261 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL17098 | — | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL16303 | — | IC50 | = | 58700.0 | nM | 4.23 |
| CHEMBL16342 | — | IC50 | = | 77400.0 | nM | 4.11 |
| CHEMBL16589 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL279648 | — | IC50 | > | 100000.0 | nM | - |