Compound Detail
CHEMBL16315
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Basic Information
| ChEMBL ID | CHEMBL16315 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZXFRFPSZAKNPQQ-UHFFFAOYSA-N |
2
Targets
7
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
279.3
MW (Da)
0.61
ALogP
5
HBA
3
HBD
103.8
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 5.85 | 5.535 | 1400.0 | 4 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 4.92 | 4.57 | 12100.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 1400.0 | nM | 5.85 | Inhibition of [3H]AMPA binding to AMPA receptor of rat brain membranes. | - |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice. | - |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 4800.0 | nM | 5.32 | Inhibition of [3H]AMPA binding to AMPA receptor of rat brain membranes. | - |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 6000.0 | nM | 5.22 | Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice. | - |
| Glutamate NMDA receptor | IC50 | = | 12100.0 | nM | 4.92 | Inhibition of [3H]-CGS-19,755 binding to NMDA receptor of rat brain membranes. | - |
| Glutamate NMDA receptor | IC50 | = | 26400.0 | nM | 4.58 | Inhibition of [3H]-CGS-19,755 binding to NMDA receptor of rat brain membranes. | - |
| Glutamate NMDA receptor | IC50 | = | 61000.0 | nM | 4.21 | Inhibition of 40 uM NMDA induced depolarizations in a rat cortical slice. | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00185-6 | Glutamate receptor ionotropic, AMPA | 4 |
| - | 10.1016/S0960-894X(97)00185-6 | Glutamate NMDA receptor | 4 |
Data from ChEMBL 36 via Core Engine