Assay Detail
Binding
CHEMBL644177
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Inhibition of [3H]AMPA binding to AMPA receptor of rat brain membranes.
21
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid ampa receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.08 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16303 | — | — | 3 | 5.89 |
| CHEMBL16315 | — | — | 2 | 5.85 |
| CHEMBL16261 | — | — | 1 | 5.37 |
| CHEMBL17098 | — | — | 1 | 5.37 |
| CHEMBL16360 | — | — | 1 | 5.21 |
| CHEMBL279120 | — | — | 1 | 4.66 |
| CHEMBL435755 | — | — | 1 | 4.33 |
| CHEMBL280498 | — | — | 1 | 4.17 |
| CHEMBL16289 | — | — | 1 | - |
| CHEMBL16944 | — | — | 1 | - |
| CHEMBL16243 | — | — | 1 | - |
| CHEMBL280054 | — | — | 1 | - |
| CHEMBL279527 | — | — | 1 | - |
| CHEMBL279648 | — | — | 1 | - |
| CHEMBL417625 | — | — | 1 | - |
| CHEMBL16589 | — | — | 1 | - |
| CHEMBL16342 | — | — | 1 | - |
| CHEMBL274226 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16303 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL16315 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL16303 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL17098 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL16261 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL16315 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL16360 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL279120 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL435755 | — | IC50 | = | 46800.0 | nM | 4.33 |
| CHEMBL16303 | — | IC50 | = | 55400.0 | nM | 4.26 |
| CHEMBL280498 | — | IC50 | = | 66900.0 | nM | 4.17 |
| CHEMBL16944 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL417625 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274226 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16342 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16589 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL279648 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL279527 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL280054 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16289 | — | IC50 | > | 100000.0 | nM | - |