Compound Detail
CHEMBL17098
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL17098 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MNVQONXYNHRFDP-MMWGEVLESA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
333.4
MW (Da)
1.87
ALogP
6
HBA
3
HBD
103.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 5.37 | 4.865 | 4300.0 | 2 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 4.7 | 4.7 | 20100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 4300.0 | nM | 5.37 | Inhibition of [3H]AMPA binding to AMPA receptor of rat brain membranes. | - |
| Glutamate NMDA receptor | IC50 | = | 20100.0 | nM | 4.7 | Inhibition of [3H]-CGS-19,755 binding to NMDA receptor of rat brain membranes. | - |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 43300.0 | nM | 4.36 | Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice. | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00185-6 | Glutamate receptor ionotropic, AMPA | 2 |
| - | 10.1016/S0960-894X(97)00185-6 | Glutamate NMDA receptor | 2 |
Data from ChEMBL 36 via Core Engine