Assay Detail
Binding
CHEMBL749992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-CGS-19,755 binding to NMDA receptor of rat brain membranes.
19
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid ampa receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.74 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16944 | — | — | 1 | 5.19 |
| CHEMBL16342 | — | — | 1 | 4.96 |
| CHEMBL16315 | — | — | 2 | 4.92 |
| CHEMBL279648 | — | — | 1 | 4.85 |
| CHEMBL17098 | — | — | 1 | 4.70 |
| CHEMBL16303 | — | — | 3 | 4.01 |
| CHEMBL280498 | — | — | 1 | - |
| CHEMBL16261 | — | — | 1 | - |
| CHEMBL417625 | — | — | 1 | - |
| CHEMBL274226 | — | — | 1 | - |
| CHEMBL279527 | — | — | 1 | - |
| CHEMBL280054 | — | — | 1 | - |
| CHEMBL16243 | — | — | 1 | - |
| CHEMBL16360 | — | — | 1 | - |
| CHEMBL16289 | — | — | 1 | - |
| CHEMBL435755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16944 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL16342 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL16315 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL279648 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL17098 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL16315 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL16303 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL435755 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16289 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16360 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL280054 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL279527 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16303 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274226 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL417625 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16261 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL280498 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16303 | — | IC50 | > | 100000.0 | nM | - |