Assay Detail
Functional
CHEMBL784010
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Compound was evaluated for the inhibition of glutamate-stimulated calcium influx (GSCI); (N=1)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.52 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145350 | — | — | 1 | 7.21 |
| CHEMBL349923 | — | — | 1 | 6.85 |
| CHEMBL351301 | — | — | 1 | 6.80 |
| CHEMBL435581 | — | — | 1 | 6.68 |
| CHEMBL160716 | — | — | 1 | 6.41 |
| CHEMBL158540 | — | — | 1 | 5.92 |
| CHEMBL158858 | — | — | 1 | 5.75 |
| CHEMBL162352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145350 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL349923 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL351301 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL435581 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL160716 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL158540 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL158858 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL162352 | — | IC50 | = | 765000.0 | nM | - |