Compound Detail
CHEMBL145350
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL145350 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QWPKWRYYGDVPFN-DZGCQCFKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
215.3
MW (Da)
3.24
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.80
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 7.26 | 7.26 | 55.2 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 7.21 | 7.21 | 61.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 55.2 | nM | 7.26 | Evaluated for their affinity at the PCP site for displacement of [3H]TCP in rat ... | 8459395 |
| Rattus norvegicus | IC50 | = | 61.0 | nM | 7.21 | Compound was evaluated for the inhibition of glutamate-stimulated calcium influx... | 8459395 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9484497 | 10.1021/jm970059p | Lysosomal Pro-X carboxypeptidase | 1 |
| 8459395 | 10.1021/jm00058a002 | Glutamate NMDA receptor | 1 |
| 8459395 | 10.1021/jm00058a002 | Rattus norvegicus | 1 |
| 8459395 | 10.1021/jm00058a002 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine