Assay Detail
Binding
CHEMBL872844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for their affinity at the PCP site for displacement of [3H]TCP in rat brain homogenates
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.18 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162352 | — | — | 1 | 8.73 |
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 8.54 |
| CHEMBL157931 | — | — | 1 | 8.00 |
| CHEMBL435581 | — | — | 1 | 7.95 |
| CHEMBL158523 | — | — | 1 | 7.87 |
| CHEMBL349923 | — | — | 1 | 7.78 |
| CHEMBL351301 | — | — | 1 | 7.66 |
| CHEMBL1795070 | — | — | 1 | 7.52 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 7.44 |
| CHEMBL145350 | — | — | 1 | 7.26 |
| CHEMBL347859 | — | — | 1 | 7.18 |
| CHEMBL160716 | — | — | 1 | 7.10 |
| CHEMBL349852 | — | — | 1 | 7.02 |
| CHEMBL158675 | — | — | 1 | 6.97 |
| CHEMBL305904 | ETOXADROL | 2.0 | 1 | 6.97 |
| CHEMBL158540 | — | — | 1 | 6.95 |
| CHEMBL158858 | — | — | 1 | 6.85 |
| CHEMBL349315 | — | — | 1 | 6.80 |
| CHEMBL349819 | — | — | 1 | 6.60 |
| CHEMBL159154 | — | — | 1 | 6.52 |
| CHEMBL160855 | — | — | 1 | 6.49 |
| CHEMBL348500 | — | — | 1 | 6.46 |
| CHEMBL159098 | — | — | 1 | 6.28 |
| CHEMBL161405 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162352 | — | IC50 | = | 1.84 | nM | 8.73 |
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 2.92 | nM | 8.54 |
| CHEMBL157931 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL435581 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL158523 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL349923 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL351301 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1795070 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL145350 | — | IC50 | = | 55.2 | nM | 7.26 |
| CHEMBL347859 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL160716 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL349852 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL158675 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL305904 | ETOXADROL | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL158540 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL158858 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL349315 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL349819 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL159154 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL160855 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL348500 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL159098 | — | IC50 | = | 528.0 | nM | 6.28 |
| CHEMBL161405 | — | IC50 | = | 3935.0 | nM | 5.41 |