Assay Detail
Functional
CHEMBL784060
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Excitatory activity in the rat cortical slice model.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.76 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315663 | — | — | 1 | 4.77 |
| CHEMBL268762 | — | — | 1 | 4.75 |
| CHEMBL88184 | — | — | 1 | - |
| CHEMBL273291 | — | — | 1 | - |
| CHEMBL9752 | — | — | 1 | - |
| CHEMBL9822 | — | — | 1 | - |
| CHEMBL268472 | — | — | 1 | - |
| CHEMBL9758 | — | — | 1 | - |
| CHEMBL10047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315663 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL268762 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL88184 | — | EC50 | = | 330000.0 | nM | - |
| CHEMBL273291 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL9752 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL9822 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL268472 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL9758 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL10047 | — | EC50 | = | 630000.0 | nM | - |